The adrenal axis (hypothalamic-pituitary-adrenal axis) refers to a complex set of interactions and feedback loops between the hypothalamus, pituitary and adrenal glands. This system regulates the body’s response to stress, immune function, energy expenditure, mood, emotions and libido.
What are the adrenal glands?
The adrenal cortex is responsible for producing cortisol and aldosterone.
How cortisol is regulated
How aldosterone is regulated
1. Low blood volume triggers release of angiotensin II.
2. Angiotensin II stimulates the adrenal cortex to produce aldosterone.
Aldosterone has a number of different actions:
3. Aldosterone’s actions result in a net increase in blood volume.
4. Increased blood volume inhibits production of Angiotensin II via negative feedback.
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