"Wrong" genes lead to Alzheimer's but their action can be neutralized

Scientists from the University of California (USA) have established which gene variants in human DNA protect against the development of Alzheimer's disease, and which, on the contrary, increase the risk of the disease. After studying the processes encoded by these genes, the experts identified mechanisms that can be corrected with the help of drugs in people with an unfavorable hereditary variant. 

During the study, experts analyzed the DNA of more than 10,000 people, and half of the participants were diagnosed with Alzheimer's disease. It turned out that the most significant in terms of the prognosis of the disease is the presence of genes that regulate the work of tyrosine phosphatases. These proteins inhibit the activity of the PI3K/Akt /GSK-3ß signaling pathway, which is crucial for cell survival. 

The discovery of this mechanism opens the way for the creation of new drugs. They will inhibit the activity of tyrosine phosphatases, thereby blocking their negative impact on the pathways of cell survival. In this way, the drugs will act as the "right" genes, protecting against Alzheimer's. 

The study also found that the C1R gene, which increases the risk of gum inflammation, also increases the chances of developing Alzheimer's disease. This is consistent with earlier studies in which scientists established a link between inflammatory processes in the gums and the occurrence of neurodegenerative diseases. 

Feb. 5, 2020, 11:26 a.m.

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