Mice with hyper-long telomeres show less metabolic aging and longer lifespans

While scientists are looking for different ways to lengthen telomeres to prolong a human's life, others fear it could lead to the development of tumors. Spanish scientists dispelled these doubts: mice born with extra-long telomeres not only lived longer than their peers, but were healthier than them. The results are published in the journal Nature Communications.

Telomere shortening is associated with the development of pathologies and shortening of life in animals and humans. To slow down, stop and reverse this process will help telomerase-an enzyme that is active in stem cells and superimposes the ends of chromosomes. However, many scientists afraid of excessive telomerase activity and abnormal chromosome length which can trigger the development of tumors.

Researchers from the Spanish national cancer center decided to assess the harm from long telomeres. They created a whole line of mice that were injected with extra-long telomeres in the embryonic stage. The authors of the work followed the life of rodents to death.

Observations showed that the mice were in better health than their relatives: they had lower body fat, low levels of low-density lipoprotein — the so-called "bad cholesterol", higher sensitivity to insulin and fewer old cells in the tissues. Long telomeres extended the average life expectancy of such mice by 13%, and the maximum-by eight percent. The risk of developing tumors did not increase: in mice of the experimental group, cases of cancer were twice as rare as in rodents of the control group.

Thus, the authors of the study were able to refute the opinion of other scientists about the dangers of telomere elongation. It is noteworthy that the experts managed to lengthen the ends of chromosomes without any genetic manipulation: they simply increased the period that embryonic cells usually spend in the stem state. This fact looks encouraging, as it opens up new ways to prolong human life.

Oct. 21, 2019, 10:56 a.m.

Similar articles:

Each percent of the fat content of milk ages us by four years

An unexpected link between the fat content of dairy products ...

Sex in old age prevents chronic diseases

An international team of experts claims that sexually active retirees ...

There was found a supplement that could protect the brain from Alzheimer's disease

Choline is a safe and easy-to-administer nutrient that is naturally ...

Artificial neural network will help in the diagnosis of Alzheimer's and Parkinson's

Scientists from the laboratory of neuroscience and cognitive technologies of ...

Parkinson's disease is also present in the blood

The behaviour of immune cells in the blood is so ...

Life in stuffy conditions "turned" laboratory mice into naked mole rats

Perhaps the secret of the long life and youth of ...

Researchers have found a new approach to the treatment of type 2 diabetes

American scientists from Weill Cornell Medicine and NewYork-Presbyterian found that ...

Grandchildren can save grandparents from loneliness and social isolation

Experts from the University clinic of Hamburg-Eppendorf (Germany) surveyed 3 ...

COOKIE

Our site collects information using cookies to be more convenient and customized to your needs interests. The purposes of the use of cookies are defined in Policy the processing of personal data .If you agree to continue to receive cookies, please click the "Accept" button. If you don't agree or want to resolve this issue later, please change your browser cookie settings.