New Treatment Restores Damaged and Missing Teeth

Researchers from Kyoto University and Fukui University in Japan have developed a monoclonal antibody treatment that helps grow new teeth. If the experiments will be successful, it will eventually allow patients to replace teeth that have fallen out or restore missing teeth from childhood. The work is published in the journal Science Advances.

Such a task is extremely difficult. After all, the genes that affect tooth growth also affect the development of the entire body. So some of the first iterations of the treatment caused birth defects in laboratory animals before the research team refined the technique.

As a result of the study, the team found that blocking a gene called USAG-1 led to an increase in the activity of a bone morphogenic protein (BMP) that determines the number of teeth in the mouth. Scientists' interference with the interaction between USAG-1 and BMP made it possible to grow missing teeth in adult mice. One session of signal transduction to the protein was enough for the emergence of a new tooth. The technique also worked on ferrets, which, according to the researchers, is important because their teeth are more similar to human teeth than those of mice.

The scientists plan to conduct experiments involving pigs and dogs. There is still a long way to go before researchers start clinical trials on humans. If all goes well, the new technique will allow patients to naturally restore missing or damaged teeth.

April 1, 2021, 12:58 p.m.

Similar articles:

A previously unknown organ, the tubular salivary glands, was found in the human body

Medical researchers from the Netherlands made an unexpected discovery in ...

Brain cells that control the “body's time” have been detected

Scientists at Southwestern University in the United States have identified ...

Yoga reduces chronic lower back pain and tai chi relieves acute pain

About 80% of people experience lower back pain throughout their ...

Intermittent fasting improves liver health

Researchers from the University of Sydney (Australia) conducted experiments on ...

Balanced protein intake will help you avoid losing muscle mass with age

Specialists from the University of Birmingham School of Sports, Exercise ...

Connecting a donor lung to a live pig helped keep it viable

Donor lung transplantation is a fairly common and demanded procedure ...

Hemp seed oil reduces chronic pain

Scientists from the University of New Mexico (USA) have found ...

New 3D printer prints organs right in the body

3D printing technology is increasingly popular in medicine. With the ...

Listening to your body makes a positive body image

Awareness of how the body works and attentiveness to feelings ...

COOKIE

Our site collects information using cookies to be more convenient and customized to your needs interests. The purposes of the use of cookies are defined in Policy the processing of personal data .If you agree to continue to receive cookies, please click the "Accept" button. If you don't agree or want to resolve this issue later, please change your browser cookie settings.