Two immune proteins were found that suppress inflammation in the joints

The cause of allergic diseases and chronic inflammation is often the aggression of the own immune system against the host's tissues – such diseases are called autoimmune. So, when small and large joints are affected – rheumatoid arthritis – neutrophil immune cells attack the joint tissues, leading to chronic inflammation. In addition to joints, chronic inflammation caused by immune aggression can affect the heart, lungs, and nervous system. 

Scientists from the Karolinska University (Sweden) found that the behavior of these cells can be influenced by two proteins called interleukins: IL-4 and IL-13. It turned out that by increasing the level of these compounds in the body, it is possible to suppress the migration of neutrophils into the joint tissues and reduce the activity of inflammation.

Scientists may have discovered a key mechanism underlying the development of autoimmune diseases in general. At the moment, experts are continuing their research and plan to use the results obtained to create fundamentally new medicines for rheumatoid arthritis. 

Jan. 22, 2020, 10:52 a.m.

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