An oral anticoagulant delays the appearance of Alzheimer's disease in mice

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified a possible treatment for Alzheimer disease. The investigators have shown that treatment with the oral anticoagulant dabigatran delays the appearance of Alzheimer disease in mice.

The results of research which were published in the Journal of the American College of Cardiology (JACC) show that after a year of treatment with dabigatran, mice had no memory loss and no reduction in cerebral circulation. This treatment also reduced typical Alzheimer symptoms, including cerebral inflammation, blood vessel injury, and amyloid protein plaques.

According to experts, the effect of dabigatran in Alzheimer's is due to stimulation of cerebral blood flow, leading to improved nutrition and oxygen supply to cells. 

Further studies are needed in patients, but the research team believe that dabigatran has the potential to normalize cerebral blood flow in Alzheimer patients.

Materials provided by Eurekalert

Oct. 9, 2019, 2:14 p.m.

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