A promising drug for Alzheimer's disease has been created

An international team of scientists from the United States, China, and Spain has identified a compound that blocks amyloid production and prevents the formation of amyloid plaques in the brains of Alzheimer's patients. This effect is achieved by suppressing the activity of the gamma-secretase enzyme. A study is published in the Chemical Communications journal.

One of the main causes of Alzheimer's disease is the accumulation of toxic tangles of beta-amyloid in the brain, which contribute to the death of neurons. Scientists have long been looking for safe ways to stop the process of their formation.

The group studied the functioning of gamma-secretase, one of the main "accomplices" of the development of neurodegeneration. This enzyme is responsible for cutting and recycling various proteins, including APP (beta-amyloids are "scraps" of this protein). Scientists were looking for ways that could prevent gamma-secretase from cutting the APP.

Using a computer algorithm, they created a C1 molecule that can attach to the APP and block the interaction between this protein and gamma-secretase. By this mechanism, C1 stopped the formation of new clusters of beta-amyloid.

So far, scientists have conducted experiments at the cellular level. Next, they intend to start testing on experimental animals and, if successful, on humans. Perhaps, if the substance really turns out to be safe for mammals, then the world will have a cure for the currently incurable Alzheimer's disease.

Feb. 4, 2020, 10:18 a.m.

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