Genetic factors define the development of diseases by only 5-10%

Canadian researchers from the University of Alberta conducted the largest meta-analysis, summarizing data from 569 genetic studies over two decades, and concluded that the link between most human diseases and genetics is very low, only 5-10%. This means that DNA does not determine human fate. The results are published in PLOS One.

In their work, the researchers studied the relationship between gene mutations, known as single nucleotide polymorphisms (snips), and various diseases and conditions. Many snips, or genetic markers, are considered risk factors for hundreds of diseases, but the analysis has shown that this relationship is highly questionable.

David Wishart, one of the co-authors of the study, writes that the vast majority of diseases, including many types of cancer, diabetes, Alzheimer's disease, depends on genetic factors only by 5-10% and no more.

However, there are exceptions: for example, for Crohn's disease, protein-losing enteropathy, age-related macular degeneration the genetic factor is 40-50%.

Despite these rare exceptions, it has become apparent that in most cases the development of diseases is associated with metabolic disorders, environmental and lifestyle factors or exposure to dangerous bacteria, viruses and toxic substances. 

That is why scientists say that analysis of metabolism, chemical levels, proteins, and microbiome composition can provide a more accurate diagnosis of diseases.

This study also highlights the need for a safe environment around humans, high-quality food, air, water, etc. to reduce the likelihood of disease.

Dec. 25, 2019, 11:48 a.m.

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