The rate at which a woman age depends on the number of births

Scientists at the University of Pennsylvania have found a correlation between the number of births during a woman's lifetime and the rate of her biological aging. In a study conducted by scientists, less than three or more than four births that resulted in live births were found to accelerate the rate of aging after menopause. Experts find it difficult to name the cause of rapid aging in childless or small women who give birth. At the same time, scientists attribute the acceleration of age-related changes at birth to the "overconsumption" of body energy for carrying, giving birth, and breastfeeding.

The conclusions of the specialists are based on the data of the survey of 4418 women who participated in the National Health and Nutrition Survey of the Centers for Disease Control and Prevention. Scientists compared data on the number of births that resulted in the birth of live babies with levels of nine biomarkers. These biomarkers allowed assessing the metabolic health of women, kidney, liver, immune system functions, anemia (anemia), and inflammatory processes in the body.

After analyzing the data, experts found a "U-dependence" between the number of live births and accelerated biological aging. The number of aging biomarkers was increased both in women who reported zero or a small number of live births and in mothers with many children (more than four children). Dependence was maintained even when other factors such as chronological age and lifestyle were taken into account.

- The study results show that pregnancy and childbirth can alter and disrupt the regulation of several different physiological systems that affect the rate of aging after menopause," explains one of the authors of the study, Talia Shirazi. - This is consistent with the metabolic, immunological, and endocrinological changes that occur in the body during pregnancy and lactation, as well as the various risks of diseases associated with pregnancy and reproductive resources in general.

According to experts, a large amount of energy is used for pregnancy, childbirth, and breastfeeding, which affects the work of various systems of the body, including immunity, metabolism, regulation of blood pressure. Problems associated with the dysfunction of these systems often manifest themselves in menopause, when the protective role of female sex hormones estrogen decreases. This leads to the fact that women who give birth often have an increased risk of death from diabetes, kidney disease, and hypertension.

Dec. 2, 2020, 10:43 a.m.

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