Mitochondrial transplantation will help treat dementia, cancer, and heart disease

A team of researchers from the University of California at Irvine (USA) has proven that the mitochondrion transplant method can "reset" damaged cells. In the future, this procedure will treat many dangerous cardiovascular, metabolic, neurodegenerative and cancer diseases. The results have been published in the Journal of the American Heart Association.

Mitochondria are peculiar "energy stations" of cells, their dysfunction can lead to cell weakening and death. American scientists decided to check whether mitochondrial transplantation can keep the viability of the cell.

By means of differential centrifugation, healthy mitochondria were isolated from skeletal muscle cells and injected into heart muscle cells. To find out how they "took root" in the new place, scientists conducted several tests, which provided important information about cell metabolism and how well cells consume and produce energy. The tests were done in 2, 7, 14 and 28 days.

As the results showed, the condition of cells improved after two days, but the therapeutic effect was reduced later. According to the authors of the study, this means the possibility to "reload" the cells, and treatment can be particularly effective in conditions of exacerbation of the disease.

The method of mitochondrion transplantation proved to be just as effective in experiments with other cell lines. The possibility of mitochondrion transplantation from rat cells to human cells (i.e. from species to species) was also confirmed.

Further, scientists intend to find out whether transplanted mitochondria can establish a connection with the nucleus of the host cell, as well as how long they can be taken in the new "residence".

March 25, 2020, 10:43 a.m.

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