Scientists have found a connection between Alzheimer's disease and fungi living in the intestines

Scientists at the University of Wake Forest, North Carolina, USA, have found a link between the presence of fungi in the intestines and the risk of cognitive impairment leading to Alzheimer's disease. The experiment also found that a certain diet style - a fat-rich Mediterranean diet - helps to reduce the proportion of fungi in the intestines and reduce Alzheimer's biomarkers in the cerebrospinal fluid. 

Mikobiom (from Dr. - Greek. μύκης - fungus) is a part of the intestinal microbiota represented by fungi. The fungus component of the microbiome is poorly studied, but recently some data have emerged on the relationship between the presence of these microorganisms in the intestine and the risk of various disorders.

Scientists from North Carolina conducted a pilot study involving 17 elderly people. Six participants had no cognitive problems and formed a control group, while eleven had cognitive impairment and Alzheimer's biomarkers were found in the cerebrospinal fluid. The experts performed genetic analysis - sequencing the ITS1 gene of fungal rRNA in all participants. It turned out that the subjects with cognitive impairment have an increased proportion of some fungi (nine species in total). 

Repeated genetic analysis was carried out six weeks later: during this time, participants followed a special diet style. It was called the "modified Mediterranean ketogenic diet" (MMKD), a variant of the Mediterranean fatty diet. 

It was found that following this diet for a month and a half resulted in a decrease in the proportion of fungi in the intestine. In addition, the concentration of Alzheimer's biomarkers in cerebrospinal fluid has decreased. 

- Even though we don't fully understand the connection between the proportion of fungi in the intestines and the development of Alzheimer's disease, this is the first study that has paid attention to the impact of these microbes on our mental health," said chief researcher, associate professor of molecular medicine Hariom Yadav. - We also found that eating habits such as a fat-rich Mediterranean diet help reduce harmful fungi in the intestines and reduce the level of Alzheimer's biomarkers. 


Sept. 1, 2020, 10:21 a.m.

Similar articles:

Alzheimer's symptoms can be predicted from the sites where plaques accumulate in the brain

Alzheimer's is a neurodegenerative disease that most often develops with ...

The reaction of the pupil will tell about the Alzheimer's onset

Scientists from the University of California in San Diego (USA ...

Study pinpoints Alzheimer’s plaque emergence early and deep in the brain

Alzheimer’s disease, such as an accumulation of amyloid protein plaques ...

The love hormone can bring back memories to Alzheimer's patients

Deterioration of memory and loss of learning ability are key ...

Regrets about the past and concerns about the future increase the risk of Alzheimer's development

People who are prone to experiences and negative thoughts, over ...

Protein misfolding as a risk marker for Alzheimer’s disease – up to 14 years before the diagnosis

In symptom-free individuals, the detection of misfolded amyloid-β protein in ...

Influenza and pneumonia vaccination reduces the risk of Alzheimer's disease

Regular flu and pneumonia vaccination can be used not only ...

Jumping and stretching slowed brain damage in Alzheimer's

The search for methods that will help to stop or ...

Orientation problems in the digital world have helped detect Alzheimer's disease

Alters in the brain, typical for Alzheimer's disease, begin long ...


Our site collects information using cookies to be more convenient and customized to your needs interests. The purposes of the use of cookies are defined in Policy the processing of personal data .If you agree to continue to receive cookies, please click the "Accept" button. If you don't agree or want to resolve this issue later, please change your browser cookie settings.