Scientists have come up with a new approach to the treatment of genetically caused premature aging

Geneticists from the Institute of Molecular Oncology in Italy and the Karolinska Institute in Sweden have developed a new method of treating childhood progeria, or Hutchinson-Guilford syndrome, a disease characterized by an accelerated aging process. Experiments on human cell lines and laboratory mice have shown that antisense oligonucleotide therapy can be effective.

Progeria is a rare genetic disease that affects about one person in 18 million. The average life expectancy in this condition is 13 years. 

The reason is a mutation of the LMNA gene, in which the protein progerin disrupting the functioning of cells and leading to accelerated aging is synthesized.

Scientists have long been trying to develop an effective treatment for this disease, but only now they are closer to this goal. 

Swedish and Italian researchers collected cell samples from children with progeria to study telomere dysfunction and the accumulation of telomeric non-coding RNA that is not translated into protein. Experts decided to reduce the level of transcription of such RNA and thereby normalize the process of cell division by adding antisense oligonucleotides - short sequences of nucleic acid that can attach to the RNA molecules of mutant LMNA genes and suppress the synthesis of progerin.

Mice with progeria who received oligonucleotide therapy increased maximum and average life expectancy by 44% and 24%, respectively.

According to the authors, this discovery is extremely important, since such therapy can be useful not only for the treatment of progeria but also for the normalization of aging processes (progerin is also found in the cells of older people). In the long term, such treatment can delay the aging of people who do not suffer from genetic disorders.

In the future, scientists intend to research healthy people to study in more detail the role of this protein in the development of age-related changes.

Nov. 19, 2019, 10:54 a.m.

Similar articles:

Lifestyle predicts the risk of heart disease with the same accuracy as a DNA test

Coronary heart disease causes the death of over seven million ...

AI predicts risks of brain diseases based on blood analysis

Canadian researchers from The Montreal Neurological Institute and Hospital and the Ludmer ...

After 40 years, the risk of heart attacks and strokes increases by 10 times, especially in men

Stroke and myocardial infarction are the leading cause of death ...

The cause of cancer cell immortality has been discovered

Pan-Cancer Analysis of Whole Genomes (PCAWG) is a large-scale project ...

New Alzheimer's risk gene discovered

In the present study, researchers analyzed Alzheimer's Disease Sequencing Project ...

Scientists have discovered an enzyme that inhibits the development of Parkinson's disease

Researchers from Stanford (USA) and the University of Dundee (UK ...

Life is shortened not only by obesity and hypertension but also by a genetic predisposition

Hypertension and overweight have a negative impact on life expectancy ...

Dying cells send "farewell messages", which update the body

The cellular composition of the body is constantly updated. The ...

"Wrong" genes lead to Alzheimer's but their action can be neutralized

Scientists from the University of California (USA) have established which ...


Our site collects information using cookies to be more convenient and customized to your needs interests. The purposes of the use of cookies are defined in Policy the processing of personal data .If you agree to continue to receive cookies, please click the "Accept" button. If you don't agree or want to resolve this issue later, please change your browser cookie settings.