Scientists have identified a new cause of Alzheimer's disease

A team of researchers from Case Western Reserve University (USA) identified a protein that promotes the formation of toxic plaques in the brain - Alzheimer's disease marker. The discovery will help scientists understand how to treat a dangerous neurodegenerative disease. The results have been published in Nature Communications.

The accumulation of beta-amyloids in the brain is one of the main signs of Alzheimer's disease. The more beta-amyloid plaques, the worse the prognosis and symptoms. 

American scientists studied the nature of brain neurodegeneration in laboratory mice with the disease and found the FAM222A gene and its associated protein, an aggregating beta-amyloid protein. 

The researchers decided to inject aggregates into healthy mice. As a result, rodents accelerated the formation of toxic plaques in the brain, leading to inflammation and impaired cognitive function of rodents. 

When scientists inhibited the action of protein, they saw that plaques became smaller, the level of inflammation decreased and cognitive impairment decreased.

Thus, the authors of the study conclude that protein aggregates may become a new therapeutic target for slowing down the development of Alzheimer's disease.

Jan. 24, 2020, 10:32 a.m.

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