A study on mice found a cure for aging

A team of scientists from the Buck Institute for Research on Aging (California, USA) found that alpha-ketoglutaric acid (AKG) helps to avoid the development of age-related diseases, slow down the aging process and extend life. Despite the fact that the effectiveness of this substance has been proven on mice, the researchers believe that similar results can be applied to humans, but it is necessary to test. A scientific article about it has been published in the journal Cell Metabolism, and the preprint of the work is available on the bioRxiv website.

Alpha-ketoglutaric acid is necessary for many cellular processes in the body (e.g., for the oxidation of organic substances in the cell). Due to its broad role, it is of great interest to scientists in various fields, espesially gerontologists: AKG is known to influence several age-related processes, including the proliferation of stem cells and the development of osteoporosis. In a person between 40 and 80 years of age, the level of alpha-glutaric acid in the body is reduced by at least 10 times and can be replenished by taking nutritional supplements.

In a new experiment, scientists have proven that AKG can prolong the life of laboratory mice (previously it was shown that it works the same way on round worms). Specialists observed this in two rodent cohorts, which began to give AKG along with food when they reached 18 months of age.

The team found that the metabolite increased life expectancy and survival rate of females in the first cohort by 16.6 and 19.7 percent respectively. For the second cohort, these rates increased by 10.5 and 8 percent respectively. Survival rate of males remained practically unchanged, but average life expectancy increased by 9.6% and 12.8% in the first and second cohorts, respectively.

In addition, mice have significantly improved their health: after several months of taking AKG, males and females have lower levels of inflammatory factors in the body compared to congeners who did not receive a supplement. The former also have reduced phenotypic signs of aging, such as piloerection, discoloration and deterioration of wool, gait disorders, hearing loss, etc.

Scientists intend to continue research on how alpha-ketoglutaric acid can affect the slowing down of the aging process and prolong life. They want to conduct additional experiments to test the effect of this substance on humans.

Photo: journal.pinkrabbit.com

Sept. 3, 2020, 10:23 a.m.

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