Relationship between the amount of coffee consumed and mental health described
A study by scientists from Fudan University (China) has established a statistical link between daily coffee consumption and the risk of developing affective and stress disorders. During the analysis of data from 461,586 participants from the UK Biobank (UK Biobank), who were followed for an average of 13.4 years, a J-shaped relationship was identified. This means that both a complete absence of the drink in the diet and an excessive amount of it are correlated with higher risks for mental health compared to moderate doses.
The optimal amount of consumption, which was associated with the lowest risk of depression and anxiety, was found to be two to three 250-ml cups of coffee per day. In this range, the protective effect was most pronounced, with a stronger effect in men compared to women. However, exceeding this threshold of five or more cups per day was associated with an increased risk of mental health issues. Therefore, the positive effects of coffee on cognitive and emotional well-being are limited to a specific range of consumption.
The biological mechanism of coffee’s effect is due to the ability of caffeine to block adenosine receptors, preventing the brain from signaling fatigue, and stimulating the release of dopamine. Dopamine is involved in the processes of motivation and feelings of satisfaction, and its deficiency is often observed in depressive states. The study also analyzed the genetic characteristics of the participants, which determine the rate of caffeine metabolism. The research found that individual biological differences in the processing of this substance do not significantly affect the overall pattern of the relationship between coffee consumption and mental health.
These results can be used by medical specialists in developing recommendations for lifestyle changes for the prevention of mental disorders. It is emphasized that coffee is not a universal solution, as individual sensitivity to caffeine varies: in some people, even small doses can provoke tachycardia, anxiety and tremor. Further study of the issue will clarify how different methods of grain processing (ground, instant or decaffeinated coffee) affect the long-term mental health indicators of the population.
Published
April, 2026
Category
Medicine
Duration of reading
3-4 minutes
Share
Source
Scientific journal of Affective Disorders. Article: Daily coffee drinking and mental health outcomes: Sex differences and the role of caffeine metabolism genotypes
Don’t miss the most important science and health updates!
Subscribe to our newsletter and get the most important news straight to your inbox